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Cellular toxicity of toluene on mouse gamete cells and preimplantation embryos

F D Yelian et al. Arch Toxicol. 1992.

*Note: Certain Nail polish contain toluene (per EWG Skin Deep)


Abstract

Toluene is an aromatic hydrocarbon, which has been used in the paint, lacquer and glue industry. It has been detected in municipal water supplies. Previous mouse in vivo studies indicated that toluene administrated by gavage increased the embryonic mortality. The present in vitro study demonstrated that a concentration of toluene higher than 8.67 micrograms/ml not only decreased sperm motility and inhibited fertilization, but also significantly increased preimplantation embryo degeneration.

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